Genomes do not accurately represent

Landgrave Ernest of Hesse-Rheinfels-Rotenburg was from 1649 to 1658 Landgrave of Hesse-Rheinfels and from 1658 until his death Landgrave of Hesse-Rheinfels-Rotenburg. Because his brothers died young, all later Landgraves in the Rotenburg Quarter are descendants of Ernest. Hence, Ernest is known as the ancestor of the Catholic Rotenburg Quarter, a group of junior lines of the House of Hesse.

A reference genome is a digital nucleic acid sequence database, assembled by scientists as a representative example of the set of genes in one idealized individual organism of a species. As they are assembled from the sequencing of DNA from a number of individual donors, reference genomes do not accurately represent the set of genes of any single individual organism. Instead, a reference provides a haploid mosaic of different DNA sequences from each donor. For example, one of the most recent human reference genomes, assembly GRCh38/hg38, is derived from >60 genomic clone libraries. There are reference genomes for multiple species of viruses, bacteria, fungus, plants, and animals. Reference genomes are typically used as a guide on which new genomes are built, enabling them to be assembled much more quickly and cheaply than the initial Human Genome Project. Reference genomes can be accessed online at several locations, using dedicated browsers such as Ensembl or UCSC Genome Browser.